Crosswinds East Metro Arts and Science School is a year-round secondary school serving students from St. Paul and 9 surrounding suburban member districts. It is the only school in the State of Minnesota to offer the International Baccalaureate Middle Years Programme, years 1 (6th grade) – 5 (10th grade), housed in one building.

Note: A separate application is required to apply to this school.

Open School's progressive programs are rooted in  the tenets of open and constructivist education and self-directed learning. The district's only K-12 school, Open's academic program is designed for self-motivated and independent learners who want a family-like environment.

Humboldt Senior High School offers a comprehensive curriculum with "rigor, relevance, and relationships" for all students. In the 9th Grade Academy, all students take core courses in English, math, social students and science in scheduled groups. Advisory focuses on helping students develop the tools to have a plan for life after high school, including a "Six-Year Plan" that is required for all students.

Highland Park Senior High’s International Baccalaureate (IB) program is a comprehensive and rigorous two-year academic program for highly motivated students interested in a pre-university program. IB courses are offered across the curriculum and students choose how to participate in the program.

Harding High School is a comprehensive high school offering an educational program tailored to individual student needs and interests while promoting community and social awareness. Harding has five Small Learning Communities: Ninth Grade Academy; Academy of Fine Arts; Human Services Academy; Medical and Environmental Studies Academy; and Science, Engineering and Industrial Technology Academy.